Mononeuritis multiplex is a painful, asymmetrical, asynchronous sensory and motor peripheral neuropathy involving isolated damage to at least 2 separate nerve areas. Multiple nerves in random areas of the body can be affected. As the condition worsens, it becomes less multifocal and more symmetrical. Mononeuropathy multiplex syndromes can be distributed bilaterally, distally, and proximally throughout the body. Mononeuritis multiplex actually is a group of disorders, not a true, distinct disease entity. Typically, the condition is associated with, but not limited to, systemic disorders such as the following: Diabetes; Vasculitis; Amyloidosis; Direct tumor involvement; Polyarteritis nodosa; Rheumatoid arthritis; Systemic lupus erythematosus; Paraneoplastic syndromes; Mononeuritis multiplex also may be associated with Lyme disease, Wegener granulomatosis, Sj�gren syndrome, cryoglobulinemia, hypereosinophilia, temporal arteritis, scleroderma, sarcoidosis, idiopathic thrombocytopenic purpura, leprosy, acute viral hepatitis A, acute parvovirus B-19 infection, and acquired immunodeficiency syndrome (AIDS). Persons with one occurrence of mononeuritis multiplex are more prone to a recurrence.